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Mouse Anti-Human CD107b/LAMP-2-Alexa Fluor 488
- 382.78€
Product Details
| Alternative Names | |
| Alternative name | Anti-Mouse Anti-Human CD107b/LAMP-2-Alexa Fluor 488, Murine Anti-Human CD107b/LAMP-2-Alexa Fluor 488, Mus musculus Anti-Homo sapiens CD107b/LAMP-2-Alexa Fluor 488, CD107b/LAMP-2, N/A |
| Clonality | |
| Clonality | Information regarding the clonality of Mouse Anti-Human CD107b/LAMP-2-Alexa Fluor 488 is available on request. |
| Clone | |
| Clone | H4B4 |
| Concentration | |
| Concentration | N/A |
| Form/Appearance | |
| Form/Appearance | Alexa Fluor 488 (AF488) Conjugate |
| Gene name | |
| Gene name | N/A |
| Gene name synonyms | |
| Gene name synonyms | N/A |
| Host organism | |
| Host organism | Mouse |
| Immunoglobulin isotype | |
| Immunoglobulin isotype | IgG1 |
| Other gene names | |
| Other gene names | N/A |
| Other names | |
| Other names | N/A |
| Purification method | |
| Purification method | N/A |
| Species reactivity | |
| Species reactivity | Human |
| Specificity and cross-reactivity | |
| Specificity and cross-reactivity | Human CD107b/LAMP-2 CD107b, also known as lysosomal-associated membrane protein 2 (LAMP-2), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107b is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-2 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium.1-7 |
| Storage and shipping | |
| Storage and shipping | The fluorescein (FITC), Alexa Fluor 488 (AF488), and Alexa Fluor 647 (AF647) conjugates are supplied as 100 tests in 1.0 mL of PBS/NaN3. Store Mouse Anti-Human CD107b/LAMP-2-Alexa Fluor 488 at +4 degrees Celsius. Temperature variations in the range +1 to +7 degrees Celsius are tolerable. Freezing of Mouse Anti-Human CD107b/LAMP-2-Alexa Fluor 488 is NOT recommended. |
| Tested for | |
| Tested for | Flow Cytometry (FACS), Immunohistochemistry (IHC) |
