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| Alternative Names | |
| Alternative name | Anti-Mouse Anti-Human Foxp3-FITC, Murine Anti-Human Foxp3-FITC, Mus musculus Anti-Homo sapiens Foxp3-FITC, Foxp3, N/A |
| Clonality | |
| Clonality | Information regarding the clonality of Mouse Anti-Human Foxp3-FITC is available on request. |
| Clone | |
| Clone | SB151b |
| Concentration | |
| Concentration | N/A |
| Form/Appearance | |
| Form/Appearance | Fluorescein (FITC) Conjugate |
| Gene name | |
| Gene name | N/A |
| Gene name synonyms | |
| Gene name synonyms | N/A |
| Host organism | |
| Host organism | Mouse |
| Immunoglobulin isotype | |
| Immunoglobulin isotype | IgG1 |
| Other gene names | |
| Other gene names | FOXP3; FOXP3; JM2; AIID; IPEX; PIDX; XPID; DIETER; IPEX |
| Other names | |
| Other names | FOXP3; FOXP3; JM2; AIID; IPEX; PIDX; XPID; DIETER; IPEX |
| Purification method | |
| Purification method | N/A |
| Species reactivity | |
| Species reactivity | Human |
| Specificity and cross-reactivity | |
| Specificity and cross-reactivity | Human Foxp3 (Mr ~57 kDa). Does not cross react with Mouse Foxp3. T regulatory cells (Originally called T suppressor cells) are a subpopulation of T cells. Their major roles are to suppress excess immune response of other cells and to maintain tolerance of self-antigens. Initially, researchers used CD4 and CD25 (IL-2 receptor) to identify T suppress subpopulation and purified CD4+CD25+ T cells were used for T cells Suppression Assay, however some other activated T cells also express CD25.1,2 The most convincible molecular marker of Treg cells is Forkhead box protein 3 (Foxp3) which is expressed in the nucleus.3 Anti-Foxp3 antibodies are now widely applied to identify the roles of Treg cells in the development of many diseases, such as cancer, autoimmune disease, and organ transplantation.4,5,6 Scientists found that the over-activation of Treg cells may cause cancer cells to escape from immune surveillance 5. Conversely, patients with autoimmune diseases such as psoriasis, systemic lupus erythematous (SLE) have relative dysfunction of Foxp3 positive cells.7,8 Immunologists are trying to induce immune tolerance in organ transplantation using Treg cells.6 |
| Storage and shipping | |
| Storage and shipping | Lyophilized antibodies may be transported at ambient temperature and stored for short terms at +4 degrees Celsius and at -20 for long term storage. Antibodies in liquid form can be shipped and stored for short terms at +4 degrees Celsius, for long term storage (up to one year) 25-50% glycerol or ethylene glycol has to added and the vial must be stored at -20°C. |
| Tested for | |
| Tested for | Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blot (WB) |
