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Rat Anti-Mouse CD8a/Ly-2-Alexa Fluor 488
- 348.35€
Product Details
| Alternative Names | |
| Alternative name | Anti-Rat Anti-Mouse CD8a/Ly-2-Alexa Fluor 488, Rat Anti-Murine CD8a/Ly-2-Alexa Fluor 488, Rattus norvegicus Anti-Mus musculus CD8a/Ly-2-Alexa Fluor 488, CD8a/Ly-2, N/A |
| Clonality | |
| Clonality | Information regarding the clonality of Rat Anti-Mouse CD8a/Ly-2-Alexa Fluor 488 is available on request. |
| Clone | |
| Clone | 53-6.7 |
| Concentration | |
| Concentration | N/A |
| Form/Appearance | |
| Form/Appearance | Alexa Fluor 488 (AF488) Conjugate |
| Gene name | |
| Gene name | N/A |
| Gene name synonyms | |
| Gene name synonyms | N/A |
| Host organism | |
| Host organism | Rat |
| Immunoglobulin isotype | |
| Immunoglobulin isotype | IgG2a |
| Other gene names | |
| Other gene names | N/A |
| Other names | |
| Other names | N/A |
| Purification method | |
| Purification method | N/A |
| Species reactivity | |
| Species reactivity | Mouse |
| Specificity and cross-reactivity | |
| Specificity and cross-reactivity | alpha chain of the murine CD8 heterodimer, Mr 32-34 kDa In the mouse, CD8 exists in two forms: (i) a CD8 heterodimer composed of an alpha chain (CD8alpha/Lyt-2) and a beta chain (CD8beta/Lyt-3); and (ii) a homodimer of two alpha chains. The heterodimer is found on the surface of essentially all thymocytes and the "suppressor/cytotoxic" subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8alpha without CD8beta. It has been suggested that CD8+beta- T cells mature extrathymically, while development of the CD8alpha+beta+ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8alpha+ cells. The 53-6.7 monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2. 1-8 |
| Storage and shipping | |
| Storage and shipping | The Alexa Fluor 488 (AF488) conjugate is supplied as 0.1mg in 0.2mL of PBS/NaN3. Store Rat Anti-Mouse CD8a/Ly-2-Alexa Fluor 488 at +4 degrees Celsius. Temperature variations in the range +1 to +7 degrees Celsius are tolerable. Freezing of Rat Anti-Mouse CD8a/Ly-2-Alexa Fluor 488 is NOT recommended. |
| Tested for | |
| Tested for | Flow Cytometry (FACS), Immunohistochemistry (IHC) |
