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Mouse Anti-Mouse CD45.1/Ly-5.1-Alexa Fluor 488
- 348.35€
Product Details
| Alternative Names | |
| Alternative name | Anti-Mouse Anti-Mouse CD45.1/Ly-5.1-Alexa Fluor 488, Murine Anti-Murine CD45.1/Ly-5.1-Alexa Fluor 488, Mus musculus Anti-Mus musculus CD45.1/Ly-5.1-Alexa Fluor 488, CD45.1/Ly-5.1, N/A |
| Clonality | |
| Clonality | Information regarding the clonality of Mouse Anti-Mouse CD45.1/Ly-5.1-Alexa Fluor 488 is available on request. |
| Clone | |
| Clone | A20 |
| Concentration | |
| Concentration | N/A |
| Form/Appearance | |
| Form/Appearance | Alexa Fluor 488 (AF488) Conjugate |
| Gene name | |
| Gene name | N/A |
| Gene name synonyms | |
| Gene name synonyms | N/A |
| Host organism | |
| Host organism | Mouse |
| Immunoglobulin isotype | |
| Immunoglobulin isotype | IgG2a |
| Other gene names | |
| Other gene names | N/A |
| Other names | |
| Other names | N/A |
| Purification method | |
| Purification method | N/A |
| Species reactivity | |
| Species reactivity | Mouse |
| Specificity and cross-reactivity | |
| Specificity and cross-reactivity | Mouse C45.1 (Leukocyte Common Antigen) The CD45 antigen is an essential regulator of leukocyte activation and development, and is now known to be a protein tyrosine phosphatase, e.g. CD45 is able to dephosphorylate the Src family of protein kinases.1, 2 This activity is now known to be required for signal transduction induced by T and B cell antigen receptor engagement, cytokine signaling and Fc receptor stimulation.1, 2 The functional state of CD45 also has a pronounced effect on lymphocyte development. CD45 exists in multiple forms, such as the restricted variants (CD45R; see companion products 1660, 1665, 1675, 1685 and 1820) and as allelic forms CD45.1/Ly-5.1 and CD45.2/Ly-5.2. The former arises as a result of alternative splicing of different exons. The specificity of antibodies to CD45.1 and CD45.2 has been exploited in studies where resolution of donor and recipient cells is essential, such as in gene therapy or bone marrow transplantation.3, 4 The monoclonal antibody A20 recognizes all mouse leukocytes expressing the CD45.1 allotype. |
| Storage and shipping | |
| Storage and shipping | The Alexa Fluor 488 (AF488), Alexa Fluor 647 (AF647), and Pacific Blue (PacBlu) conjugates are supplied as 0.1mg in 0.2mL of PBS/NaN3. Store Mouse Anti-Mouse CD45.1/Ly-5.1-Alexa Fluor 488 at +4 degrees Celsius. Temperature variations in the range +1 to +7 degrees Celsius are tolerable. Freezing of Mouse Anti-Mouse CD45.1/Ly-5.1-Alexa Fluor 488 is NOT recommended. |
| Tested for | |
| Tested for | Flow Cytometry (FACS), Fluorescence Microscopy |
