Search for products here
| Alternative Names | |
| Alternative name | Anti-Hamster Anti-Mouse CD103-Pacific Blue, Hamster Anti-Murine CD103-Pacific Blue, Hamster Anti-Mus musculus CD103-Pacific Blue, CD103, N/A |
| Clonality | |
| Clonality | Information regarding the clonality of Hamster Anti-Mouse CD103-Pacific Blue is available on request. |
| Clone | |
| Clone | 20000000 |
| Concentration | |
| Concentration | N/A |
| Form/Appearance | |
| Form/Appearance | Pacific Blue (PacBlu) Conjugate |
| Gene name | |
| Gene name | N/A |
| Gene name synonyms | |
| Gene name synonyms | N/A |
| Host organism | |
| Host organism | Armenian Hamster IgG |
| Immunoglobulin isotype | |
| Immunoglobulin isotype | IgG |
| Other gene names | |
| Other gene names | N/A |
| Other names | |
| Other names | N/A |
| Purification method | |
| Purification method | N/A |
| Species reactivity | |
| Species reactivity | Mouse |
| Specificity and cross-reactivity | |
| Specificity and cross-reactivity | The CD103/alphaIELbeta7 integrin complex (Mr 160 and 115 kDa peptides). CD103 is a member of the integrin series of adhesion molecules. This antigen defines a developmentally important subset of T cells, namely mucosal T cells including all IEL (intraepithelial lymphocytes) and ~20% of lamina propria T cells. Expression of CD103 is more restricted outside these mucosal organs, appearing at lower levels on T cell subsets of the lymph node, dendritic epidermis and periphery.1-3 In non-epithelial CD103+ T cells there is a bias toward expression on CD8+.cells. The 2E7 mAb exhibits antigen immunoprecipitation patterns similar if not identical to the rat anti-mouse CD103 mAb M290.1 The 2E7 mAb is reported to have signal-inducing activity in a redirected lysis assay and to co-stimulate IEL and CD8+ lymph node cells in conjunction with anti-TCR in vitro, which runs counter to the usual inhibition of CTL by anti-integrins.1 This co-stimulatory activity is also shared by the mAb M290.4 The property of costimulation is not unique to the mouse since the combination of anti-human IEL plus anti-TCR will produce similar proliferation in human cells, with the exception that CD8+ cells are not stimulated.5 |
| Storage and shipping | |
| Storage and shipping | The Alexa Fluor 488 (AF488), Alexa Fluor 647 (AF647), and Pacific Blue (PacBlu) conjugates are supplied as 0.1mg in 0.2mL of PBS/NaN3. Store Hamster Anti-Mouse CD103-Pacific Blue at +4 degrees Celsius. Temperature variations in the range +1 to +7 degrees Celsius are tolerable. Freezing of Hamster Anti-Mouse CD103-Pacific Blue is NOT recommended. |
| Tested for | |
| Tested for | Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP) |
