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| Alternative Names | |
| Alternative name | Anti-Rat Anti-Mouse CD5/Ly-1-UNLB, Rat Anti-Murine CD5/Ly-1-UNLB, Rattus norvegicus Anti-Mus musculus CD5/Ly-1-UNLB, CD5/Ly-1, N/A |
| Clonality | |
| Clonality | Information regarding the clonality of Rat Anti-Mouse CD5/Ly-1-UNLB is available on request. |
| Clone | |
| Clone | 53-7.3 |
| Concentration | |
| Concentration | N/A |
| Form/Appearance | |
| Form/Appearance | Purified (UNLB) Antibody |
| Gene name | |
| Gene name | N/A |
| Gene name synonyms | |
| Gene name synonyms | N/A |
| Host organism | |
| Host organism | Rat |
| Immunoglobulin isotype | |
| Immunoglobulin isotype | IgG2a |
| Other gene names | |
| Other gene names | N/A |
| Other names | |
| Other names | N/A |
| Purification method | |
| Purification method | N/A |
| Species reactivity | |
| Species reactivity | Mouse |
| Specificity and cross-reactivity | |
| Specificity and cross-reactivity | CD5/Lyt-1, Mr 67 kDa CD5/Lyt-1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells.1-3 It has been identified as the major ligand of the B-cell antigen CD72.4, 5 The frequency of CD5+ B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells (reviewed in 6). Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression.7-12 It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors.13, 14 |
| Storage and shipping | |
| Storage and shipping | The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store Rat Anti-Mouse CD5/Ly-1-UNLB at +4 degrees Celsius. Temperature variations in the range +1 to +7 degrees Celsius are tolerable. Freezing of Rat Anti-Mouse CD5/Ly-1-UNLB is NOT recommended. |
| Tested for | |
| Tested for | Flow Cytometry (FACS) |
