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| Alternative Names | |
| Alternative name | Anti-Rat Anti-Mouse Foxp3-FITC, Rat Anti-Murine Foxp3-FITC, Rattus norvegicus Anti-Mus musculus Foxp3-FITC, Foxp3, N/A |
| Clonality | |
| Clonality | Information regarding the clonality of Rat Anti-Mouse Foxp3-FITC is available on request. |
| Clone | |
| Clone | SB168a |
| Concentration | |
| Concentration | N/A |
| Form/Appearance | |
| Form/Appearance | Fluorescein (FITC) Conjugate |
| Gene name | |
| Gene name | N/A |
| Gene name synonyms | |
| Gene name synonyms | N/A |
| Host organism | |
| Host organism | Rat |
| Immunoglobulin isotype | |
| Immunoglobulin isotype | IgG2a |
| Other gene names | |
| Other gene names | FOXP3; FOXP3; JM2; AIID; IPEX; PIDX; XPID; DIETER; IPEX |
| Other names | |
| Other names | FOXP3; FOXP3; JM2; AIID; IPEX; PIDX; XPID; DIETER; IPEX |
| Purification method | |
| Purification method | N/A |
| Species reactivity | |
| Species reactivity | Mouse |
| Specificity and cross-reactivity | |
| Specificity and cross-reactivity | Mouse Foxp3 (Mr ~57 kDa). Does not cross react with Human Foxp3. T regulatory cells (Originally called T suppressor cells) are a subpopulation of T cells. Their major roles are to suppress excess immune response of other cells and to maintain tolerance of self-antigens. Initially, researchers used CD4 and CD25 (IL-2 receptor) to identify T suppress subpopulation and purified CD4+CD25+ T cells were used for T cells Suppression Assay, however some other activated T cells also express CD25.1,2 The most convincible molecular marker of Treg cells is Forkhead box protein 3 (Foxp3) which is expressed in the nucleus.3 Anti-Foxp3 antibodies are now widely applied to identify the roles of Treg cells in the development of many diseases, such as cancer, autoimmune disease, and organ transplantation.4,5,6 Scientists found that the over-activation of Treg cells may cause cancer cells to escape from immune surveillance 5. Conversely, patients with autoimmune diseases such as psoriasis, systemic lupus erythematous (SLE) have relative dysfunction of Foxp3 positive cells.7,8 Immunologists are trying to induce immune tolerance in organ transplantation using Treg cells.6 |
| Storage and shipping | |
| Storage and shipping | The fluorescein (FITC) and Alexa Fluor 647 (AF647) conjugates are supplied as 0.1 mg in 0.2 mL PBS/NaN3. Store Rat Anti-Mouse Foxp3-FITC at +4 degrees Celsius. Temperature variations in the range +1 to +7 degrees Celsius are tolerable. Freezing of Rat Anti-Mouse Foxp3-FITC is NOT recommended. |
| Tested for | |
| Tested for | N/A |
