Search for products here
Rat Anti-Mouse CD62L/L-selectin-Pacific Blue
- 348.35€
Product Details
| Alternative Names | |
| Alternative name | Anti-Rat Anti-Mouse CD62L/L-selectin-Pacific Blue, Rat Anti-Murine CD62L/L-selectin-Pacific Blue, Rattus norvegicus Anti-Mus musculus CD62L/L-selectin-Pacific Blue, CD62L/L-selectin, N/A |
| Clonality | |
| Clonality | Information regarding the clonality of Rat Anti-Mouse CD62L/L-selectin-Pacific Blue is available on request. |
| Clone | |
| Clone | MEL-14 |
| Concentration | |
| Concentration | N/A |
| Form/Appearance | |
| Form/Appearance | Pacific Blue (PacBlu) Conjugate |
| Gene name | |
| Gene name | N/A |
| Gene name synonyms | |
| Gene name synonyms | N/A |
| Host organism | |
| Host organism | Rat |
| Immunoglobulin isotype | |
| Immunoglobulin isotype | IgG2a |
| Other gene names | |
| Other gene names | N/A |
| Other names | |
| Other names | N/A |
| Purification method | |
| Purification method | N/A |
| Species reactivity | |
| Species reactivity | Mouse |
| Specificity and cross-reactivity | |
| Specificity and cross-reactivity | CD62L/L-selectin, Mr 90 kDa CD62L, also known as L-selectin, is a type I transmembrane glycoprotein with lectin-like and Epidermal Growth Factor-like domains.1, 2 It binds to sialylated oligosaccharide determinants on high endothelial venules (HEV) in peripheral lymph nodes.1, 2 In the mouse, CD62L is expressed on most thymocytes and on peripheral leukocytes, including B and T lymphocytes, neutrophils, monocytes and eosinophils.3-7 This member of the selectin family of cell adhesion molecules appears to be required for lymphocyte homing to peripheral lymph nodes and for leukocyte extravasation at sites of inflammation.1, 2, 7-9 Expression of CD62L on lymphocytes and neutrophils is rapidly down-regulated upon cell activation and the level of CD62L expression, along with other markers, distinguishes naive T cells from effector/memory T cells.10-13 The monoclonal antibody MEL-14 blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and the late stages of leukocyte rolling.1, 2, 7-9 |
| Storage and shipping | |
| Storage and shipping | The Alexa Fluor 488 (AF488), Alexa Fluor 647 (AF647) and Pacific Blue (PacBlu) conjugates are supplied as 0.1 mg in 0.2 mL of PBS/NaN3. Store Rat Anti-Mouse CD62L/L-selectin-Pacific Blue at +4 degrees Celsius. Temperature variations in the range +1 to +7 degrees Celsius are tolerable. Freezing of Rat Anti-Mouse CD62L/L-selectin-Pacific Blue is NOT recommended. |
| Tested for | |
| Tested for | Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC) |
